Christina Haston is an associate professor of medical physics at UBC’s Okanagan campus. - Credit: UBCO

UBC study could spare cancer patients from side effects of radiation

Her research has drawn a connection of Chromosome 6 genes to pulmonary fibrosis susceptibility.

A UBC Okanagan researcher has determined that genes on a specific chromosome may be the answer as to why thoracic radiotherapy leads to a lung injury in some lung cancer patients.

Christina Haston, an associate professor of medical physics, recently published a study examining how Chromosome 6 can contribute to radiation-induced pulmonary fibrosis. Her study finds that genetic differences can determine whether or not this lung injury follows radiotherapy in an experimental system, according to UBCO in a news release.

“Currently, 50 per cent of cancer patients in Canada receive radiation therapy as part of their treatment course,” she said. “In addition to effects on the tumour, up to 30 per cent of these patients develop side effects to this treatment, or injuries to non-tumour tissue.”

RELATED: UBC Okanagan study evaluates virtual educational care

Pulmonary fibrosis is a progressive disease related to damaged lung tissue, making it difficult for patients to breathe and process oxygen effectively. Some lung cancer patients have developed pulmonary fibrosis after radiation, while patients with other cancers have developed it after receiving a specific cancer medication called Bleomycin.

“One of the limiting side effects of thoracic radiotherapy is the development of pulmonary fibrosis in a susceptible subpopulation of treated patients,” said Haston. “However, the specific pathways contributing to fibrosis susceptibility in radiotherapy patients remain unidentified.”

It has been thought that white blood cells, the body’s natural defence mechanism, may contribute to pulmonary fibrosis. Building on this, her research has drawn a connection of Chromosome 6 genes to fibrosis susceptibility, the release said.

She examined the susceptibility to pulmonary fibrosis on lab mice after radiation therapy and on mice after treatment of Bleomycin. The mice with a replaced Chromosome 6 were protected from both radiation-induced and Bleomycin-induced pulmonary fibrosis.

RELATED: Globe trotting biology student to study at UBCO

“The recent findings by our lab have specifically identified these genetic differences to reside in Chromosome 6,” she added, explaining that her work may open the door to individualized cancer treatments, depending on a person’s specific genetic makeup.

Her study, published in Radiation Research, was supported by the Canadian Institutes of Health Research.

“This research aims to develop a pre-treatment marker based on knowledge of specific genes of radiation injury response,” she said. “Such a marker could significantly affect Canadians with cancer, by sparing side effects and increasing the dose to the tumour which may, in turn, increase cure rates.”


edit@kelownacapnews.com

Like us on Facebook and follow us on Twitter.

Just Posted

Defense says burden of proof not met in double murder case against Oak Bay father

Closing statements begin in trial for man accused of killing daughters Christmas 2017

Sealand was much more than killer whales, says ex-employee

Former Sealasd trainer revisits Sealand of the Pacific in talk

UPDATED: Hundreds gather to reflect and remember UVic students killed in bus crash

Campus community invited to reflect, support one another

Oak Bay United preparing entirely new development application

Three scenarios being considered for Granite Street redesign

Province overrules View Royal; plans to build handyDART facility

View Royal Mayor calls province’s actions “heavy handed” and “unusual”

WATCH: United Way #Drive4Five event launches campaign to raise $5 million

More than 80,000 lives changed last year by the United Way

Crime Stoppers most wanted for Greater Victoria for the week of September 17

Greater Victoria Crime Stoppers is seeking the public’s help in locating the… Continue reading

Man who crushed Nanaimo RCMP cars with stolen truck gets more jail time

Majore Jackson, 34, sentenced to two more years in jail in provincial court in Nanaimo

B.C. dog breeder banned again after 46 dogs seized

The SPCA seized the animals from Terry Baker, 66, in February 2018

Surrey mom allegedly paid $400,000 for son in U.S. college bribery scam

Xiaoning Sui, 48, was arrested in Spain on Monday night

Three dogs found shot dead in Prince George ditch

The three adult dogs appeared to be well cared for before being found with gunshot wounds, BC SPCA says

B.C. party bus company to be monitored after 40 intoxicated teens found onboard

Police received tip teens and young adults were drinking on party buses and limousines in Surrey

Rick Mercer calls out Conservative candidate in B.C. for fake meme

‘Not true. All fake. Please Stop,’ tweeted Rick Mercer in response

Bear killed in Kimberley after chasing girl, wreaking havoc on town

This particular brown-coloured bear has been the subject of many calls this summer; very food habituated, CO says

Most Read